This study investigated the mediating role of psychological grit in the relationship between quality of work life and perception of brain drain among medical doctors in TNorth Central Nigeria. The cross-sectional research method was used. Participants were 371 medical doctors aged 23 – 66 years old who had spent between 1 year to 37 years as medical doctors. They were 192(51.8%) males and 177(47.7%) females and 2(0.5%) who did not indicate their gender. Data were collected using the Perception of Brain Drain Questionnaire (PBDQ); the adapted Walton Quality of Life Scale, and the Grit Scale by Duckworth (2007). Results of regression and simple mediation analyses showed quality of work-life as a significant predictor of perception of brain drain among medical doctors in North-central Nigeria,with safety and health issues in the workplace, social integration and political instability significantly increasing brain drain while other components of quality of work-life, including fair and adequate compensation, and opportunity to use and develop human capacity, significantly reduce perception of brain drain among medical doctors. While findings further indicate that psychological grit (passion and perseverance) significantly lowers perception of brain drain, it was not found to be a significant mediator in the relationship between quality of work-life and perception of brain drain whereby quality of work-life dimensions, especially issues of safety, health,and political instability, increases positive perception of brain drain with or without psychological grit. Based on the findings, it was recommended that, apart from improving the quality of work-life of the medical doctors through fair and adequate compensation, psychologists should be involved in the selection of candidates into medical training institutions to select candidates who have passion for the job in addition to competence.