This study investigated Knowledge, self-esteem and intimacy on health status disclosure among people living with hepatitis in Makurdi metropolis. Using a cross Tsectional design method, 256 hepatitis patients made up of 160 males and 96 females randomly selected to participate in the study responded to a Questionnaire developed from four different instruments namely The Viral Hepatitis Questionnaire for Knowledge (VHQ) The Rosenberg's Self-esteem Scale (RSES), The Functional Analytic Psychotherapy Intimacy Scale (FAPIS) and the 15 Item questionnaire for self-disclosure. Data collected were analysed with simple linear regression for the first and second hypothesis, multiple linear regression for the third hypothesis and standard multiple regression for the fourth hypothesis. Results of the study indicates that knowledge [R2=.697, F(1,254)=584.337, p