In care-giving occupation such as nursing, nurses are at a risk of experiencing compassion fatigue and burnout. This study examined the influence of self-transcendence on Iprofessional quality of life among nurses in Makurdi Metropolis. This study adopted a cross-sectional survey research design. TheSimple Random and convenience sampling were used to select hospital (FMC and General Hospital, Makurdi) and one hundred and seventy- one participants; 35(20.5%) male and 136(79.5%) female respectively. Their ages ranged from 20 to 65 years. Two standardized instruments; Quality of Life Scale RV and Self- Transcendence Scale (STS) were used to collect data. Three hypotheses were tested using simple regression analysis. The findings from hypothesis one showed a significant influence of self-transcendenceon quality of life among nurses. Hypothesis two showed a significant influence of self-transcendence on compassion fatigue among nurses. Hypothesis three revealed a significant influence of self-transcendence on burnout among nurses. It was therefore concluded that, self-transcendence predisposes nurses in Makurdi metropolis to quality of life. It was recommended that nurses be trained on self-transcendence periodically to let go of self-centeredness and ego-boundaries. This can be achieved through partnership between Nursing Council of Nigeria and Nigerian Association of Clinical Psychologist for periodic training of nurses.