This study examined the influence of social support, life satisfaction, and psychological well-being of caregivers of stroke patients at Federal Medical Center in TMakurdi with 3 hypotheses. A researcher adopted a quantitative study and cross- sectional survey research design on 325 participants aged 20-55 years. Data was collected through a self-administered questionnaire using a psychological well-being scale, social support scaleand life satisfaction scale, and statistical analysis was done using regression analysis. Results revealed that there was a significant influence of perceived social support on psychological well-being among caregivers of stroke patients; perceived life satisfaction significantly influenced the psychological well-being among caregivers; there was a significant joint influence of social support and life satisfaction on psychological well-being among caregivers of stroke patients. In conclusion social support and life satisfaction significantly influenced psychological well-being of caregivers of stroke patients. Therefore, the study recommended that the management of the Federal Medical Center, Makurdi, should implement psychological intervention measures to increase the well-being of caregivers of stroke patients. Government, non-governmental organizations, and other individuals with a compassionate interest in stroke victims should offer social support to enhance caregivers' psychological well-being. The promotion of intervention programs such as recreational therapy, self-care practices, stress management techniques, and finding sources of joy and fulfillment outside caregiving responsibilities is also recommended to enhance their overall well-being.